Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow
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چکیده
Zarbock, Anthony C. Bruce, Andrew W. Pryor, Bradley D. Gelfand, Brett R. Blackman, Martin Brian L. Harry, John M. Sanders, Ryan E. Feaver, Melissa Lansey, Tracy L. Deem, Alexander in ApoE-Deficient Mice Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2008 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.108.164707 2008;28:2003-2008; originally published online August 7, 2008; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/28/11/2003 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2008/08/08/ATVBAHA.108.164707.DC1.html Data Supplement (unedited) at:
منابع مشابه
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice.
OBJECTIVE Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) has recently been shown to form an essential element of a mechanosensory complex that mediates endothelial responses to fluid shear stress. The aim of this study was to determine the in vivo role of PECAM-1 in atherosclerosis. METHODS AND RESULTS We crossed C57BL/6 Pecam1(-/-) mice with apolipoprotein E-deficient (Apoe(-/...
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OBJECTIVE Polymorphisms in the platelet-endothelial cell adhesion molecule (PECAM-1)-1 gene are linked to increased risk of coronary artery disease. Because PECAM-1 has been demonstrated to form a mechanosensory complex that can modulate inflammatory responses in murine arterial endothelial cells, we hypothesized that PECAM-1 contributes to atherogenesis in a shear-dependent and site-specific m...
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Atherosclerosis is a chronic inflammatory disease of large arteries in which lesion development preferentially occurs at vessel sites exposed to rapid changes in flow. We have previously shown that platelet endothelial cell adhesion molecule (PECAM-1), a surface receptor of the immunoglobulin superfamily, is involved in mechanosensing of rapid changes in flow. We wondered whether apolipoprotein...
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The vascular endothelium integrates a variety of humoral stimuli and biophysical forces to maintain patent microvascular and macrovacular beds. At the interface between the blood and vessel wall, endothelial cells communicate in both directions by the release of growth factors, cytokines, and bioactive mediators to maintain vascular homeostasis. Endothelial dysfunction is central for acute syst...
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تاریخ انتشار 2008